| Cellular and Animal Models in Human Genomics Research Contributor(s): Walz, Katherina, Young, Juan I. |
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ISBN: 0128165731 ISBN-13: 9780128165737 Publisher: Academic Press OUR PRICE: $166.25 Product Type: Paperback Published: July 2019 |
| Additional Information |
| BISAC Categories: - Medical | Genetics - Science | Life Sciences - Genetics & Genomics - Science | Life Sciences - Molecular Biology |
| Physical Information: 0.6" H x 7.5" W x 9.1" (1.05 lbs) 226 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. |