| Advances in Systems Biology 2004 Edition Contributor(s): Opresko, Lee K. (Editor), Gephart, Julie M. (Editor), Mann, Michaela B. (Editor) |
|
 |
ISBN: 0306483149 ISBN-13: 9780306483141 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: May 2004 Annotation: This book is based on the proceedings of the inaugural symposium "Northwest Symposium for Systems Biology." Particular focus is on identifying current breakthrough technologies and their application to important model systems. By integrating computational sciences, high-throughput technologies and quantitative biology, this book will advance the understanding of not just the function of individual genes, proteins and smaller molecules like hormones, but also how all of these molecules interact within a cell. This volume will be a collection of presentations on four topics that comprise the scope of the Genomes to Life project recently announced by the Department of Energy. They are four aspects of a system biology approach to understanding microbial communities. These topics include complex microbial systems, gene regulatory networks, molecular machines/ multiprotein complexes and computational techniques. The range of material covered will include the following: -Molecular biological methods for the analysis of complex microbial communities and the use of specific bacterial species for bioremediation, -The study of gene regulation through the use of genomics as well as specific regulation in bacteria (by methylation) and in yeast (via signal transduction pathways), -Structure and function of multiprotein complexes involved in protein degradation, muscle function and protein kinase attachments in cells, -Computational approaches to the analysis of large data sets to yield useful information. |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Molecular Biology - Science | Life Sciences - Genetics & Genomics - Science | Life Sciences - Biochemistry |
| Dewey: 571 |
| LCCN: 2003068653 |
| Series: Advances in Experimental Medicine and Biology |
| Physical Information: 0.57" H x 6.76" W x 9.9" (1.02 lbs) 108 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: AbouttheNorthwestSymposiumforSystemsBiology This publication is the proceedingsofthe Pacific Northwest National Laboratory (PNNL) inaugural meeting of the Northwest Symposium for Systems Biology, held October 17 and 18,2002, in Richland, Washington. This is the40thyear in which the laboratory has held an interdisciplinary science symposium to address important biologicalquestions. Inyearspast, theunifyingthemewasenvironmentalsciences.This yearwebegananewseriesofsymposiaonsystemsbiology.Aparticularfocusofthese symposiawill beon identifyingcurrentbreakthroughtechnologiesand theirapplication toimportantmodelsystems. PNNLestablished theBiomolecularSystemsInitiative(BSI) toexploit the unique andinnovativetechnologiesdevelopedhereatthelaboratory, especiallyattheWilliamR. Wiley Environmental Molecular Sciences Laboratory (EMSL). The BSI is a multidisciplinary research program thatfocuses on theareasofresearch that will drive biology in the post-genomic era. It combines cutting-edge capabilities for high- throughputproteomics, cellimaging, quantitativebiology, andcomputationalbiology. To understand complex biological systems, scientists must acquire detailed knowledgeaboutcellsignaling, andabouthownetworksregulatecellfunctions.Thiswill requireanintegratedeffortacrossavarietyofresearchdisciplines: molecularandcellular biology, biochemistry, physics, mathematics, and information science. The BSI is working to provide opportunities for scientists from different disciplines to gatherand discusscell networksatallscalesaswell asapproachesforunderstandingthemolecular componentsofthesenetworks. The theme of this year's symposium was the U.S. Department ofEnergy's new Genomes to Life (GTL) program. GTL has the eventual goal of a fundamental, comprehensive, andsystematicunderstandingoflife. In its initial implementation, GTL focusesonpost-genomicapproachestounderstanding - ComplexMicrobialSystems - ComputationalMethods - MolecularMachines: Multiproteincomplexes - GeneRegulatoryNetworks. |