| Computational Methods for Protein Structure Prediction and Modeling: Volume 1: Basic Characterization 2007 Edition Contributor(s): Xu, Ying (Editor), Xu, Dong (Editor), Liang, Jie (Editor) |
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ISBN: 0387333193 ISBN-13: 9780387333199 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: December 2006 Annotation: Volume one of this two volume sequence focuses on the basic characterization of known protein structures as well as structure prediction from protein sequence information. The 11 chapters provide an overview of the field, covering key topics in modeling, force fields, classification, computational methods, and struture prediction. Each chapter is a self contained review designed to cover (1) definition of the problem and an historical perspective, (2) mathematical or computational formulation of the problem, (3) computational methods and algorithms, (4) performance results, (5) existing software packages, and (6) strengths, pitfalls, challenges, and future research directions. Key Features
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| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biophysics - Science | Life Sciences - Biology - Science | Life Sciences - Biochemistry |
| Dewey: 572.633 |
| LCCN: 2006929615 |
| Series: Biological and Medical Physics: Biomedical Engineering |
| Physical Information: 0.93" H x 6.47" W x 9.45" (1.55 lbs) 394 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: An ultimate goal of modern biology is to understand how the genetic blueprint of cells(genotype)determinesthestructure, function, andbehaviorofalivingorganism (phenotype). At the center of this scienti?c endeavor is characterizing the bioch- ical and cellular roles of proteins, the working molecules of the machinery of life. A key to understanding of functional proteins is the knowledge of their folded str- tures in a cell, as the structures provide the basis for studying proteins' functions and functional mechanisms at the molecular level. Researchers working on structure determination have traditionally selected - dividual proteins due to their functional importance in a biological process or pa- way of particular interest. Major research organizations often have their own protein X-ray crystallographic or/and nuclear magnetic resonance facilities for structure - termination, which have been conducted at a rate of a few to dozens of structures a year. Realizing the widening gap between the rates of protein identi?cation (through DNA sequencing and identi?cation of potential genes through bioinformatics an- ysis) and the determination of protein structures, a number of large scienti?c init- tives have been launched in the past few years by government funding agencies in the United States, Europe, and Japan, with the intention to solve protein structures en masse, an effort called structural genomics. A number of structural genomics centers (factory-like facilities) have been established that promise to produce solved protein structures in a similar fashion to DNA sequencing. |