| Adhesion-Gpcrs: Structure to Function 2010 Edition Contributor(s): Yona, Simon (Editor), Stacey, Martin (Editor) |
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ISBN: 1441979123 ISBN-13: 9781441979124 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover Published: January 2011 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biology - Medical | Biochemistry - Science | Life Sciences - Biochemistry |
| Dewey: 572.69 |
| LCCN: 2010040249 |
| Series: Advances in Experimental Medicine and Biology |
| Physical Information: 0.5" H x 7.2" W x 10.5" (1.30 lbs) 199 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation. |