Limit this search to....

Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation 2013 Edition
Contributor(s): Sugiyama, Yuichi (Editor), Steffansen, Bente (Editor)
ISBN: 1461482283     ISBN-13: 9781461482284
Publisher: Springer
OUR PRICE:   $161.49  
Product Type: Hardcover - Other Formats
Published: September 2013
Qty:
Additional Information
BISAC Categories:
- Medical | Pharmacy
- Science | Chemistry - Organic
- Medical | Research
Dewey: 610
LCCN: 2013947789
Series: Aaps Advances in the Pharmaceutical Sciences
Physical Information: 0.9" H x 6.2" W x 9.2" (1.70 lbs) 317 pages
 
Descriptions, Reviews, Etc.
Publisher Description:

Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.