| Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation Softcover Repri Edition Contributor(s): Sugiyama, Yuichi (Editor), Steffansen, Bente (Editor) |
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ISBN: 1493952064 ISBN-13: 9781493952069 Publisher: Springer OUR PRICE: $161.49 Product Type: Paperback - Other Formats Published: August 2016 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacy - Science | Chemistry - Organic - Medical | Research |
| Dewey: 610 |
| Series: Aaps Advances in the Pharmaceutical Sciences |
| Physical Information: 0.7" H x 6.14" W x 9.21" (1.04 lbs) 317 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process. |