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This book offers an excellent presentation of intelligent engineering and informatics foundations for researchers in this field as well as many examples with industrial application. It contains extended versions of selected papers presented at the inaugural ACASE 2012 Conference dedicated to the Applications of Systems Engineering. This conference was held from the 6^th to the 8^th of February 2012, at the University of Technology, Sydney, Australia, organized by the University of Technology, Sydney (Australia), Wroclaw University of Technology (Poland) and the University of Applied Sciences in Hagenberg (Austria). The book is organized into three main parts. Part I contains papers devoted to the heuristic approaches that are applicable in situations where the problem cannot be solved by exact methods, due to various characteristics or dimensionality problems. Part II covers essential issues of the network management, presents intelligent models of the next generation of networks and distributed systems as well as discusses applications of modern numerical methods in large intractable systems. Part III covers salient issues of complexity in intelligent system applications. This part also contains papers and articles which discuss concurrency issues that arise when multiple systems attempt to use the same radio space and the inter-connected system applications in the field of medical simulation and training.