| Varicella-Zoster Virus 2010 Edition Contributor(s): Abendroth, Allison (Editor), Arvin, Ann M. (Editor), Moffat, Jennifer F. (Editor) |
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ISBN: 3642127274 ISBN-13: 9783642127274 Publisher: Springer OUR PRICE: $265.99 Product Type: Hardcover - Other Formats Published: August 2010 |
| Additional Information |
| BISAC Categories: - Medical | Microbiology - Medical | Infectious Diseases - Science | Life Sciences - Virology |
| Dewey: 616.914 |
| LCCN: 2010933953 |
| Series: Current Topics in Microbiology and Immmunology |
| Physical Information: 1" H x 6.1" W x 9.1" (1.54 lbs) 378 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: over many decades. Importantly, these early observationssetthestagefortheremarkableprogressthathasbeenmadeinour understandingofthemolecularbiologyofVZV, thesubtletiesofitstropismfor differentiatedhumancells, includinglymphocytesaswellasskinandneurons, and themechanismsbywhichthevirusachievesanequilibriumwiththehostsothatit persistsnotjustintheindividualbutinthehumanpopulation. v vi Preface Thepurposeofthisvolumeistoreviewkeyareasofprogressinthe?eldofVZV research, aswellasworkontherelatedSVV, writtenbythosewhohavecontributed manyofthenew?ndingsthathaveenrichedourknowledgeoftheuniquech- acteristicsofthisubiquitoushumanpathogen. AlthoughtheVZVgenomeisthe smallestamongthehumanherpesviruses, therapidlyacceleratingpaceofdiscovery about VZV and VZV host interactions re?ected in these reviews promises to continueasnewtoolsareavailableandnewhypothesesaregeneratedtoexplain howVZVhascreatedandmaintaineditsnicheinthehuman virome sos- cessfully. Further improvements in the clinical management of VZV infection shouldemergeinparallelwithbetterinsightsintoVZVmolecularvirologyand pathogenesis. Stanford, CA, June,2010 AllisonAbendroth AnnM. Arvin JenniferF. Moffat Contents TheVaricella-ZosterVirusGenome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 JeffreyI. Cohen VZVMolecularEpidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 JudithBreuer RolesofCellularTranscriptionFactorsinVZVReplication . . . . . . . . . . . . . . 43 WilliamT. Ruyechan EffectsofVaricella-ZosterVirusonCellCycleRegulatoryPathways . . . 67 JenniferF. MoffatandRebeccaJ. Greenblatt Varicella-ZosterVirusOpenReadingFrame66ProteinKinase andItsRelationshiptoAlphaherpesvirusUS3Kinases . . . . . . . . . . . . . . . . . . . . 79 AngelaErazoandPaulR. Kinchington VZVORF47SerineProteinKinaseandItsViralSubstrates . . . . . . . . . . . . . 99 TeriK. KenyonandCharlesGrose OverviewofVaricella-ZosterVirusGlycoproteinsgC, gHandgL . . . . . . 113 CharlesGrose, JohnE. Carpenter, WallenJackson, andKarenM. Duus AnalysisoftheFunctionsofGlycoproteinsEandIandTheirPromoters DuringVZVReplicationInVitroandinSkinandT-CellXenografts intheSCIDMouseModelofVZVPathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . 129 AnnM. Arvin, StefanOliver, MikeReichelt, JenniferF. Moffat, MarvinSommer, LeighZerboni, andBarbaraBerarducci Varicella-ZosterVirusGlycoproteinM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147 YasukoMoriandTomohikoSadaoka vii viii Contents VaricellaZosterVirusImmuneEvasionStrategies . . . . . . . . . . . . . . . . . . . . . . . 155 AllisonAbendroth, PaulR. Kinchington, andBarrySlobedman VZVInfectionofKeratinocytes: ProductionofCell-FreeInfectious VirionsInVivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 MichaelD. GershonandAnneA. Gershon Varicella-ZosterVirusTCellTropismandthePathogenesis ofSkinInfection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189 AnnM. Arvin, JenniferF. Moffat, MarvinSommer, StefanOliver, XibingChe, SusanVleck, LeighZerboni, andChia-ChiKu ExperimentalModelstoStudyVaricella-ZosterVirusInfection ofNeurons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 MeganSteain, BarrySlobedman, andAllisonAbendroth MolecularCharacterizationofVaricellaZosterVirusinLatently InfectedHumanGanglia: PhysicalStateandAbundanceofVZV DNA, QuantitationofViralTranscriptsandDetection ofVZV-Speci?cProteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 229 YevgeniyAzarkh, DonGilden, andRandallJ. Cohrs NeurologicalDiseaseProducedbyVaricellaZosterVirusReactivation WithoutRash . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 DonGilden, RandallJ. Cohrs, RaviMahalingam, andMariaA. Nagel Varicella-ZosterVirusNeurotropisminSCIDMouse Human DorsalRootGangliaXenografts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 L. Zerboni, M. Reichelt, andA. Arvin RodentModelsofVaricella-ZosterVirusNeurotropism . . . . . . . . . . . . . . . . . 277 JeffreyI. Cohen SimianVaricellaVirus: MolecularVirology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 WayneL. Gray SimianVaricellaVirusPathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 RaviMahalingam, IlhemMessaoudi, andDonGilden Varicella-ZosterVirusVaccine: MolecularGenetics . . . . . . . . . . . . . . . . . . . . . 323 D. ScottSchmid VZVTCell-MediatedImmunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341 AdrianaWeinbergandMyronJ. Levin Contents ix PerspectivesonVaccinesAgainstVaricella-ZosterVirusInfections . . . . 359 AnneA. GershonandMichaelD. Gershon Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 373 . Contributors Allison Abendroth Department of Infectious Diseases and Immunology, UniversityofSydney, BlackburnBuilding, Room601, Camperdown, NSW 2006, Australia and Centre for Virus Research, Westmead Millennium Institute, Westmead, NSW2145, Australia, allison. abendroth@sydney. edu. au AnnM. Arvin StanfordUniversitySchoolofMedicine, G3 |