| The Origins of Depression: Current Concepts and Approaches: Report of the Dahlem Workshop on the Origins of Depression: Current Concepts and Approache Softcover Repri Edition Contributor(s): Angst, J. (Other), Angst, J. (Editor), Checkley, S. a. (Contribution by) |
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ISBN: 3642691315 ISBN-13: 9783642691317 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: November 2011 |
| Additional Information |
| BISAC Categories: - Medical | Psychiatry - General |
| Dewey: 616.89 |
| Physical Information: 0.98" H x 6" W x 9" (1.42 lbs) 474 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: 3 and a fraction mayor may not respond to treatment. On the behavioral level, animal research shows that a variety of experimental conditions can induce de- pression. The same is true in the field of treatment, where pharmacologically highly different drugs can equally alleviate depression in animals and hu- mans. The question as to whether this is due to a heterogeneity of depressive subjects based on different pathogenetic mechanisms is open to discussion. We can look for common features of all possible causal factors in the hope of finding a single basic mechanism. Many divergent findings may also be ex- plained as peripheral changes of a highly complicated dynamic system. In the field of psychopharmacology, a circular reasoning has become evident in the sense that originally the clinical antidepressive response was founded on empirical grounds only. In a second step, an attempt was made to characterize some clinically active compounds pharmacologically, and in a third, further compounds were developed based on aspects of the pharmaco- logical profiles. Moreover, the post hoc development of a pharmacological screening method has the serious disadvantage of delaying breakthroughs into new fields. |