| Adp-Ribosylation of Proteins: Enzymology and Biological Significance Softcover Repri Edition Contributor(s): Althaus, Felix R. (Author), Richter, Christoph (Author) |
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ISBN: 364283079X ISBN-13: 9783642830792 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: February 2012 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Cell Biology - Science | Life Sciences - Biochemistry - Medical | Oncology - General |
| Dewey: 599.013 |
| Series: Molecular Biology, Biochemistry and Biophysics Molekularbiol |
| Physical Information: 0.54" H x 6.69" W x 9.61" (0.91 lbs) 238 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions. The development of this field over the past 2 decades reflects very much a modern trend of biological research. As more detailed knowledge accumulates, enigmatic phenomena turn into concepts which create their own enigmata. This process tends to favor the development of multiple, seemingly disconnected, research lines until simplicity emerges from chaos and unifying concepts substitute for controversy. It appears that the field of ADP-ribosylation reactions has not yet attained this latter stage. For example, with the identification of two different classes of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla- tion and poly-ADP-ribosylation reactions, the field split very early into two separate branches of research. With the present volume, we have divided the task of reviewing these two classes of ADP- ribosylation accordingly, although their coexistence in eukaryotes may involve a closer functional linkage than hitherto recognized. |