| Sulfonamides: X-Ray Structures and Biological Studies Contributor(s): Ahmad, Waqar (Author), Butt, Asia (Author), Khan, Islam Ullah (Author) |
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ISBN: 3659155314 ISBN-13: 9783659155314 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: June 2012 |
| Additional Information |
| BISAC Categories: - Science | Chemistry - General |
| Physical Information: 0.25" H x 6" W x 9" (0.36 lbs) 104 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The use of antibiotics in the treatment of various infections of humans caused by microbes has been a great success. Over the past years there has been an increase in the resistance of microorganisms against a large number of drugs. Keeping in view the biological activity and medicinal importance of sulfonamides, new sulfonamides are being synthesized. This book describes the synthesis of N-benzyl-4-methylbenzenesulfonamide, its N-alkylated derivatives and evaluation of their anti-microbial activity. N-benzyl-4- methylbenzene sulfonamide was synthesized by the condensation of benzyl amine with p-toluene benzenesulfonylchloride. The solvent used for this reaction was water.N-alkylated derivatives were prepared by reacting N-benzyl-4-methylbenzenesulfonamide with different alkylating agents and sodium hydride using DMF as solvent. The synthesized compounds were characterized by different techniques like X-ray crystallography, FT-IR, Elemental analyzer and melting point. Evaluation of anti-microbial activity was carried out by employing deep well method against different bacterial strains.The synthesized compounds exhibited appreciable anti-microbial activity. |