Genes and Mechanisms in Vertebrate Sex Determination 2001 Edition Contributor(s): Scherer, Gerd (Editor), Schmid, Michael (Editor) |
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ISBN: 3764361689 ISBN-13: 9783764361686 Publisher: Birkhauser OUR PRICE: $132.99 Product Type: Hardcover - Other Formats Published: March 2001 |
Additional Information |
BISAC Categories: - Science | Life Sciences - Zoology - General - Science | Life Sciences - Zoology - Mammals - Medical | Research |
Dewey: 591.35 |
LCCN: 00048566 |
Series: Exs |
Physical Information: 205 pages |
Descriptions, Reviews, Etc. |
Publisher Description: Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions. |