| Hepatitis C Virus Antigen Cellular Response to HLA Class 1 Allele Contributor(s): Mahapatra, Chinmaya (Author) |
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ISBN: 3847330608 ISBN-13: 9783847330608 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: December 2011 |
| Additional Information |
| BISAC Categories: - Medical | Clinical Medicine |
| Physical Information: 0.19" H x 6" W x 9" (0.28 lbs) 80 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Clinical and virological outcomes are variable following acute infection with HCV. Chronic infection is characterized by attenuated and narrowly focused CD4+ and CD8+ T-cell responses in conjunction with reduced proliferative, cytokine, and cytolytic capacity of HCV-specific T cells and loss of antigen recognition. Conversely, CD4 and CD8 T-cell responses are maintained in individuals who clear the virus. Therefore, effective T-cell-dependent immune responses to HCV-specific viral epitopes, restricted by the presence of host human leukocyte antigens (HLA) class I (CD8 cytotoxic T cells CTL]) and class II (CD4 helper T cells), appear to make an important contribution to adaptive immunity and disease outcome. |