| The Protein Folding Problem and Tertiary Structure Prediction Softcover Repri Edition Contributor(s): Merz, Kenneth M. Jr. (Editor), Legrand, Scott M. (Editor) |
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ISBN: 1468468332 ISBN-13: 9781468468335 Publisher: Birkhauser OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: April 2012 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Molecular Biology - Gardening - Medical | Family & General Practice |
| Dewey: 610 |
| Physical Information: 1.21" H x 6.14" W x 9.21" (1.81 lbs) 581 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy- sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold- ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap- proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen- tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam- pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems. |