| Untranslated Gene Regions and Other Non-Coding Elements: Regulation of Eukaryotic Gene Expression 2013 Edition Contributor(s): Barrett, Lucy W. (Author), Fletcher, Sue (Author), Wilton, Steve D. (Author) |
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ISBN: 3034806787 ISBN-13: 9783034806787 Publisher: Springer OUR PRICE: $52.24 Product Type: Paperback - Other Formats Published: July 2013 |
| Additional Information |
| BISAC Categories: - Medical | Genetics - Science | Life Sciences - Biochemistry - Science | Life Sciences - Botany |
| Dewey: 570 |
| Series: Springerbriefs in Biochemistry and Molecular Biology |
| Physical Information: 0.2" H x 6" W x 8.9" (0.30 lbs) 56 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution. |