A Practical Guide to Rational Drug Design Contributor(s): Hongmao, Sun (Author) |
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ISBN: 0081000987 ISBN-13: 9780081000984 Publisher: Woodhead Publishing OUR PRICE: $207.90 Product Type: Hardcover Published: October 2015 |
Additional Information |
BISAC Categories: - Business & Economics | Industries - Pharmaceutical & Biotechnology - Medical | Pharmacology |
Physical Information: 0.7" H x 6.1" W x 8.9" (1.30 lbs) 292 pages |
Descriptions, Reviews, Etc. |
Publisher Description: This book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. A Practical Guide to Rational Drug Design focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes. |