| Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity: Volume 47 Contributor(s): Fambrough, Douglas M. (Editor), Benos, Dale J. |
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ISBN: 0120890305 ISBN-13: 9780120890309 Publisher: Academic Press OUR PRICE: $105.93 Product Type: Paperback - Other Formats Published: October 1999 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry - Science | Life Sciences - Molecular Biology - Medical | Biochemistry |
| Dewey: 615.7 |
| Series: Current Topics in Membranes |
| Physical Information: 0.7" H x 5.9" W x 9" (1.22 lbs) 384 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. |
