Pharmacology of G Protein Coupled Receptors: Volume 62 Contributor(s): Enna, S. J. |
|
ISBN: 0123859522 ISBN-13: 9780123859525 Publisher: Academic Press OUR PRICE: $267.30 Product Type: Hardcover - Other Formats Published: September 2011 |
Additional Information |
BISAC Categories: - Medical | Pharmacology - Medical | Biochemistry - Science | Life Sciences - Cell Biology |
Dewey: 612.015 |
LCCN: 2012471897 |
Series: Advances in Pharmacology |
Physical Information: 0.94" H x 6" W x 9" (1.57 lbs) 408 pages |
Descriptions, Reviews, Etc. |
Publisher Description: G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. |