Genome Plasticity in Health and Disease Contributor(s): Forero, Diego A., Patrinos, George P. |
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ISBN: 0128178191 ISBN-13: 9780128178195 Publisher: Academic Press OUR PRICE: $166.25 Product Type: Paperback Published: April 2020 |
Additional Information |
BISAC Categories: - Medical | Genetics - Science | Life Sciences - Genetics & Genomics - Science | Life Sciences - Molecular Biology |
LCCN: 2020935603 |
Physical Information: 288 pages |
Descriptions, Reviews, Etc. |
Publisher Description: Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. |