| Blood Cell Biochemistry: Hematopoiesis and Gene Therapy 1999 Edition Contributor(s): Fairbairn, Leslie J. (Editor), Testa, Nydia G. (Editor) |
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ISBN: 0306459620 ISBN-13: 9780306459627 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: March 1999 Annotation: This volume, the last in the excellent Blood Cell Biochemistry series, focuses specifically on gene therapy in the hematopoietic system; its applications, aspirations and problems, and provides insight as to how the hematopoietic system may be considered as a target in therapy of acquired and inherited disease of other tissues. |
| Additional Information |
| BISAC Categories: - Medical | Endocrinology & Metabolism - Medical | Internal Medicine - Science | Life Sciences - Genetics & Genomics |
| Dewey: 616.410 |
| Series: Blood Cell Biochemistry |
| Physical Information: 0.88" H x 7" W x 10" (2.00 lbs) 380 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express- ing adenosine deaminase (the defective enzyme in patients with this disorder). The partial success of this treatment was perhaps responsible for undue optimism among those proposing other gene therapy treatments within the hematopoietic system, and it has since become clear that there are a number of technical and biological difficulties to overcome before hematopoietic gene therapy becomes a mainstream therapeutic strategy. The chapters in this book evaluate the need for gene therapy in the hematopoietic system, discuss how efficient gene transfer and expression can be achieved in the target cells, highlight areas of difficulty to be addressed, and examine a number of potential applications of the gene therapy approach. The book begins with a chapter by Testa and colleagues, discussing the various sources of hematopoietic cells for both transplantation and gene therapy. |