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Antiangiogenic Cancer Therapy
Contributor(s): Davis, Darren W. (Editor), Herbst, Roy S. (Editor), Abbruzzese, James L. (Editor)
ISBN: 0367388812     ISBN-13: 9780367388812
Publisher: CRC Press
OUR PRICE:   $75.95  
Product Type: Paperback - Other Formats
Published: October 2019
Qty:
Additional Information
BISAC Categories:
- Medical | Oncology - General
- Medical | Pharmacology
- Science | Life Sciences - Cell Biology
Dewey: 616.994
Physical Information: 1.7" H x 7" W x 9.9" (4.55 lbs) 876 pages
 
Descriptions, Reviews, Etc.
Publisher Description:

Top Investigators Explore the Complexities of Angiogenesis Cancer Research

The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors.

Compiles the results of four decades of progress

Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject.

  • Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment.
  • Covers specific molecular targets for inhibiting angiogenesis in cancer therapy.
  • Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors.
  • Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers.

    • This volume celebrates progress made in four decades, and more importantly, it provi