| Transplantation of Neural Tissue Into the Spinal Cord 2006 Edition Contributor(s): Nogradi, Antal (Editor) |
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ISBN: 0387263551 ISBN-13: 9780387263557 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: January 2006 Annotation: Transplantation of Neural Tissues into the Spinal Cord presents both recent and early results from various experiments where grafts of neuronal, glial and other tissues, as well as artificial materials, were placed into the spinal cord. This book is evaluates the contribution and effect of these studies to our understanding of basic neurobiological questions. This second edition of the book provides answers to many questions which could not be answered in the first edition, and accordingly all the chapters have been extensively rewritten and edited. The findings summarized in this edition show that grafted tissue can survive and thrive in a host mammal, occasionally replace some lost function and re-establish a semblance of sophisticated and complex circuitries. These new insights are among the most exciting in neurobiology, for they challenge the view that nothing can grow or regenerate in the central nervous system and give new hope that it may be possible to treat some of the incurable diseases of the CNS. |
| Additional Information |
| BISAC Categories: - Medical | Neuroscience - Medical | Neurology - Medical | Surgery - Transplant |
| Dewey: 617.482 |
| LCCN: 2005016427 |
| Series: Neuroscience Intelligence Unit |
| Physical Information: 0.55" H x 6.59" W x 9.22" (0.88 lbs) 150 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The book gives an account of results obtained from experiments where grafts of neuronal, glial and other tissues as well as artificial materials were placed into the spinal cord. It attempts to evaluate the contributions made by these studies to our understanding of basic neurobiologies questions. These include factors that regulate neuronal growth during development as well as regenera- tion following injury to the nervous system. The model of neural transplanta- tion is also useful for the study of cell-to-cell interactions, and this applies to interactions between glial cells and neurones, between various populations of neuronal cells and finally between axons and skeletal muscle fibres. The mecha- nisms involved in the establishment of specific synaptic connections between neurones can also be investigated in this experimental paradigm. Important in- formation regarding this issue was also obtained on systems other than the spinal cord, i. e. the cerebellum, hippocampus and striatum. Although such in- formation of precise connections between the host and the grafted embryonic tissue is still lacking in the spinal cord, there is much information on the re- sponse of the host nervous system to the grafted embryonic tissue, and that of the graft to its new host environment. It appears that embryonic grafts are able to induce repair processes follow- ing injury to the nervous system. |