| Multifunctional Pharmaceutical Nanocarriers 2008 Edition Contributor(s): Torchilin, Vladimir (Editor) |
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ISBN: 0387765514 ISBN-13: 9780387765518 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: May 2008 Annotation: Multifunctional Pharmaceutical Nanocarriers intends to bring together the experts in the field of multifunctional nanopharmaceuticals to provide the reader with the cutting edge information, a critical overview of the field, and analysis of the current and future tendencies and developments to aid in the rapid developments in the field. |
| Additional Information |
| BISAC Categories: - Technology & Engineering | Biomedical - Technology & Engineering | Nanotechnology & Mems - Medical | Pharmacology |
| Dewey: 615.7 |
| LCCN: 2008920068 |
| Series: Fundamental Biomedical Technologies |
| Physical Information: 1" H x 6.1" W x 9.3" (2.05 lbs) 474 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The use of various pharmaceutical carriers to enhance the in vivo efficiency of many drugs and drug administration protocols has been well established during the last decade in both pharmaceutical research and clinical setting. Surface modification of pharmaceutical nanocarriers, such as liposome, micelles, na- capsules, polymeric nanoparticles, solid lipid particles, and niosomes, is normally used to control their biological properties in a desirable fashion and to simulta- ously make them perform various therapeutically or diagnostically important functions. The most important results of such modification include an increased stability and half-life of drug carriers in the circulation, required biodistribution, passive or active targeting into the required pathological zone, responsiveness to local physiological stimuli, and ability to serve as contrast agents for various imaging modalities (gamma-scintigraphy, magnetic resonance imaging, computed tomography, ultra-sonography). Frequent surface modifiers (used separately or simultaneously) include soluble synthetic polymers (to achieve carrier longevity); specific ligands, such as antibodies, peptides, folate, transferrin, and sugar moieties (to achieve targeting effect); pH- or temperature-sensitive lipids or polymers (to impart stimuli sensitivity); chelating compounds, such as EDTA, DTPA, and deferoxamine (to add a heavy metal-based diagnostic/contrast moiety onto a drug carrier). Certainly, new or modified pharmaceutical carriers (nanocarriers) as well as their use for the delivery of various drugs and genes are still described in many publications. |