Progress in Medicinal Chemistry: Volume 42 Contributor(s): King, F. D. (Author) |
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ISBN: 0444511431 ISBN-13: 9780444511430 Publisher: Elsevier OUR PRICE: $199.50 Product Type: Hardcover - Other Formats Published: April 2004 |
Additional Information |
BISAC Categories: - Medical | Pharmacology - Medical | Laboratory Medicine - Medical | Pharmacy |
Dewey: 615.1 |
Series: Progress in Medicinal Chemistry |
Physical Information: 0.9" H x 5.8" W x 8.5" (1.41 lbs) 393 pages |
Descriptions, Reviews, Etc. |
Publisher Description: This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections. |