| ABC Transporters and Multidrug Resistance Contributor(s): Boumendjel, Ahcène (Editor), Boutonnat, Jean (Editor), Robert, Jacques (Editor) |
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ISBN: 0470227346 ISBN-13: 9780470227343 Publisher: Wiley OUR PRICE: $170.95 Product Type: Hardcover - Other Formats Published: July 2009 Annotation: This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer. It examines ABC transporters not only at the cancer cell, but also in other important physiological localizations. This book covers these topics as well as the pharmaceutical and medicinal modulation and inhibition of ABC transporters, helping pharmaceutical researchers discover drugs to counteract multidrug resistance in diseases like cancer. |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology - Science | Life Sciences - Biochemistry |
| Dewey: 572.696 |
| LCCN: 2009013351 |
| Series: Wiley Series in Drug Discovery and Development |
| Physical Information: 1" H x 6.3" W x 9.3" (1.70 lbs) 480 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Wiley Series in Drug Discovery and Development Binghe Wang, Series Editor ABC Transporters and Multidrug Resistance Edited by Ahcene Boumendjel Jean Boutonnat Jacques Robert A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance. |
