| Bayesian Inference for Gene Expression and Proteomics Contributor(s): Do, Kim-Anh (Editor), Müller, Peter (Editor), Vannucci, Marina (Editor) |
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ISBN: 052186092X ISBN-13: 9780521860925 Publisher: Cambridge University Press OUR PRICE: $75.04 Product Type: Hardcover - Other Formats Published: July 2006 Annotation: The interdisciplinary nature of bioinformatics presents a challenge in integrating concepts, methods, software, and multi-platform data. Although there have been rapid developments in new technology and an inundation of statistical methodology and software for the analysis of microarray gene expression arrays, there exist few rigorous statistical methods for addressing other types of high-throughput data, such as proteomic profiles that arise from mass spectrometry experiments. This book discusses the development and application of Bayesian methods in the analysis of high-throughput bioinformatics data, from medical research and molecular and structural biology. The Bayesian approach has the advantage that evidence can be easily and flexibly incorporated into statistical models. A basic overview of the biological and technical principles behind multi-platform high-throughput experimentation is followed by expert reviews of Bayesian methodology, tools, and software for single group inference, group comparisons, classification and clustering, motif discovery and regulatory networks, and Bayesian networks and gene interactions. |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry - Mathematics | Probability & Statistics - Bayesian Analysis - Mathematics | Applied |
| Dewey: 572.865 |
| LCCN: 2006005635 |
| Physical Information: 1.14" H x 6.32" W x 9.24" (1.63 lbs) 437 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The interdisciplinary nature of bioinformatics presents a research challenge in integrating concepts, methods, software and multiplatform data. Although there have been rapid developments in new technology and an inundation of statistical methods for addressing other types of high-throughput data, such as proteomic profiles that arise from mass spectrometry experiments. This book discusses the development and application of Bayesian methods in the analysis of high-throughput bioinformatics data that arise from medical, in particular, cancer research, as well as molecular and structural biology. The Bayesian approach has the advantage that evidence can be easily and flexibly incorporated into statistical methods. A basic overview of the biological and technical principles behind multi-platform high-throughput experimentation is followed by expert reviews of Bayesian methodology, tools and software for single group inference, group comparisons, classification and clustering, motif discovery and regulatory networks, and Bayesian networks and gene interactions. |
Contributor Bio(s): Do, Kim-Anh: - Kim-Anh Do is a Professor in the Department of Biostatistics and Applied Mathematics at the University of Texas M. D. Anderson Cancer Center. Her research interests are in computer-intensive statistical methods with recent focus in the development of methodology and software to analyze data produced from high-throughput optimization.Vannucci, Marina: - Marina Vannucci is a Professor of Statistics at Rice University. Her research focuses on the theory and practice of Bayesian variable selection techniques and on the development of wavelet-based statistical models and their applications. Her work is often motivated by real problems that need to be addressed with suitable statistical methods.Muller, Peter: - Peter Muller is a Professor in the Department of Biostatistics and Applied Mathematics at the University of Texas M. D. Anderson Cancer Center. His research interests and contributions are in the areas of Markov chain Monte Carlo posterior simulation, nonparametric Bayesian inference, hierarchical models, mixture models and Bayesian decisions problems. |