| Nanoparticles and Brain Tumor Treatment Contributor(s): Caruso, Gerardo (Author), Caffo, Maria (Author), Raudino, Giuseppe (Author) |
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ISBN: 0791860035 ISBN-13: 9780791860038 Publisher: American Society of Mechanical Engineers OUR PRICE: $85.45 Product Type: Hardcover - Other Formats Published: October 2012 |
| Additional Information |
| BISAC Categories: - Technology & Engineering | Nanotechnology & Mems - Medical | Oncology - General |
| Dewey: 616.994 |
| LCCN: 2012289797 |
| Series: Biomedical & Nanomedical Technologies |
| Physical Information: 0.6" H x 6.2" W x 9.1" (0.60 lbs) 99 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Despite progresses in surgery, radiotherapy, and in chemotherapy, an effective curative treatment of gliomas does not yet exist. Mortality is still close to 100% and the average survival of patients with GBM is less than 1 year. The efficacy of current anti-cancer strategies in brain tumors is limited by the lack of specific therapies against malignant cells. Besides, the delivery of the drugs to brain tumors is limited by the presence of the blood brain barrier. The oncogenesis of gliomas is characterized by several biological processes and genetic alterations, involved in the neoplastic transformation. The modulation of gene expression to more levels, such as DNA, mRNA, proteins and transduction signal pathways, may be the most effective modality to down-regulate or silence some specific gene functions. Gliomas are characterized by extensive microvascular proliferation and a higher degree of vasculature. In malignant gliomas targeted therapies efficacy is low. |