| Pharmacological Control of Calcium and Potassium Homeostasis: Biological, Therapeutical, and Clinical Aspects 1995 Edition Contributor(s): Godfraind, T. (Editor), Mancia, G. (Editor), Abbracchio, M. P. (Editor) |
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ISBN: 0792336046 ISBN-13: 9780792336044 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: July 1995 Annotation: This up to date treatment of calcium and potassium channel pharmacology first presents both molecular and preclinical pharmacology data, followed by contributions on the clinical application of the drugs that modulate calcium and potassium channels. Cardiovascular data prevail, but other chapters also discuss possible roles and application to the nervous system. Further, some contributions deal with future prospects in the area. Audience: Researchers, both pharmacological and medical, working in cardiovascular medicine with strong interests in the treatment of myocardial infarction and hypertension. |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology - Medical | Cardiology - Medical | Neurology |
| Dewey: 616.106 |
| LCCN: 95019895 |
| Series: NATO Asi Series |
| Physical Information: 0.69" H x 6.14" W x 9.21" (1.30 lbs) 275 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. The present volume provides an update on the basic knowledge, the molecular targets of the two channels, and the importance the drugs that bind them have as pharmacological tools and therapeutic agents. This work was presented at the 6th International Symposium on PHARMACOLOGICAL CONTROL OF CALCIUM AND POTASSIUM HOMEOSTASIS: BIOLOGICAL, THERAPEUTICAL, AND CLINICAL ASPECTS, in Florence (Italy) on October 4-6, 1994. Because of the recent advances in the field, discussions on potassium channels were included for the first time. At least six classes of voltage-dependent calcium channels have been defined based on their physiological and pharmacological properties. Among them, L-type channels, mediating long lasting currents, are better characterized. Calcium homeostasis within the cell is not only regulated by calcium channels; intracellular calcium stores, in particular a pool contained in the lumen of specialized areas of the endoplasmic reticulum, are rapidly exchanged with the cytoplasm and playa key role in the control of calcium homeostasis. This area, however, has not yet been exploited from a therapeutic point of view. Potassium channels are present in virtually every cell type, excitable and nonexcitable, and are distinguished by structural, biophysical, and pharmacological criteria. Different classes including voltage-gated, ligand-gated, AP-sensitive, and G-protein coupled among others, have been defined by their primary regulatory and gating mechanisms. |