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Autoaffection links diverse forms of cultural criticism -- feminist theory, queer theory, film theory, postcolonial theory, Marxist cultural studies and literary criticism, the cultural studies of science and the criticism of ethnographic writing -- to the transformation and expansion of teletechnology in the late twentieth century. These theoretical approaches, Clough suggests, have become the vehicles of unconscious thought in our time.

In individual chapters, Clough juxtaposes the likes of Derridean deconstruction, Deleuzian philosophy, and Lacanian psychoanalysis. She works through the writings of Fredric Jameson, Donna Haraway, Judith Butler, Bruno Latour, Nancy Fraser, Elizabeth Grosz -- to name only a few -- placing all in dialogue with a teletechnological framework. Clough shows how these cultural criticisms have raised questions about the foundation of thought, allowing us to reenvision the relationship of nature and technology, the human and the machine, the virtual and the real, the living and the inert.