| Assembly of the Vasculature and Its Regulation 2002 Edition Contributor(s): Tomanek, Robert J. (Editor) |
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ISBN: 0817642293 ISBN-13: 9780817642297 Publisher: Birkhauser OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: March 2002 Annotation: This is the first comprehensive treatise that deals with the formation of blood vessels during embryonic development. Assembly of the Vasculature and its Regulation presents our most current understanding of vascular angiogenesis and vasculogenesis at the molecular scale. The book covers the events and regulatory factors that characterize vessel formation during the prenatal and perinatal periods. It describes the proliferation, migration and differentiation of angioblasts, their assembly into vascular tubes, the subsequent growth of these structures and the addition of medial and adventitial components to form the functional network that is the vascular system. The first half of the book details the major issues concerned with vessel formation and its regulation (growth factors and their receptors, extracellular matrix, adhesion molecules, and smooth muscle differentiation). The second half covers vascular development in a number of organs (heart, central nervous system, kidney, lung, and placenta). The book is an important reference work for all students and researchers working in vascular biology. |
| Additional Information |
| BISAC Categories: - Medical | Cardiology - Science | Life Sciences - Molecular Biology - Science | Life Sciences - Developmental Biology |
| Dewey: 571.6 |
| LCCN: 2001025378 |
| Series: Cardiovascular Molecular Morphogenesis |
| Physical Information: 0.73" H x 7.18" W x 10.28" (1.90 lbs) 279 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progressively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular mor- phogenesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or multiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardio- vascular morphogenesis that will serve not only as an important archival and didac- tic reference source for those who have recently come into the field but also as a guide to the evolution of afield that is clearly coming of age. |