| Prion Diseases 1996 Edition Contributor(s): Baker, Harry F. (Editor), Ridley, Rosalind M. (Editor) |
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ISBN: 0896033422 ISBN-13: 9780896033429 Publisher: Humana OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: April 1996 Annotation: Leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases treated range from human to animal spongiform encephalopathies and include Creutzfeldt-Jakob disease, mad cow disease, and scrapie. |
| Additional Information |
| BISAC Categories: - Medical | Neurology - Medical | Reference - Medical | Infectious Diseases |
| Dewey: 616.8 |
| LCCN: 96003408 |
| Series: Methods in Molecular Medicine |
| Physical Information: 1.03" H x 6.32" W x 9.29" (1.53 lbs) 319 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Harry Baker and Rosalind Ridley have done an admirable job in assem- bling this collection of articles that describe the methodology frequently used to study a group of CNS illnesses often referred to as the "prion diseases." Research on prions and the disorders that they cause has progressed relatively rapidly over the last decade since the discovery of the prion protein (PrP) that allowed the application of modem molecular biological and genetic tools. The power of these techniques is awesome and their use in deciphering the once mysterious prion diseases has brought a wealth of new information. Although prions are unprecedented pathogens, appearing to consist only of PrPSc molecules, the diseases that they cause are no less remarkable. The prion diseases in animals include scrapie of sheep and goats as well as "mad cow" disease or bovine spongiform encephalopathy (BSE). In the United King- dom, the epidemic of BSE has heightened public awareness of this previously obscure group of diseases such that any work in the field is likely to stir up interest in the media and become a subject of public debate. It has been diffi- cult for British investigators to work on prion diseases without being involved in these controversies. As such, several chapters have been included that deal with political and social issues surrounding prion diseases. The human prion diseases present an equally fascinating saga in which these CNS degenerations present as genetic, sporadic, and infectious illnesses. |