| G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders 1997 Edition Contributor(s): Mishra, Ram K. (Editor), Baker, Glen B. (Editor), Boulton, Alan A. (Editor) |
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ISBN: 0896034909 ISBN-13: 9780896034907 Publisher: Humana OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: July 1997 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Molecular Biology - Medical |
| Dewey: 572.68 |
| LCCN: 00000000 |
| Series: Neuromethods |
| Physical Information: 1.29" H x 6.33" W x 9.34" (1.98 lbs) 433 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12. |