| Alzheimer's Disease 2000 Edition Contributor(s): Hooper, Nigel M. (Editor) |
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ISBN: 0896037371 ISBN-13: 9780896037373 Publisher: Humana OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: December 1999 Annotation: A panel of highly skilled investigators describe in detail their state-of-the-art biochemical, cell biological, and molecular biological techniques for studying the molecular basis of Alzheimer's disease. These readily reproducible, step-by-step methods focus on work with the amyloid precursor protein and the amyloidogenic peptide A?, but also include-with the recent identification of presenilin proteins-techniques for determining the structure and biological function of these proteins. In addition, there are chapters covering the tau protein and its role in Alzheimer's disease, as well as an introductory discussion of the history of the disease, its genetic basis, and the currently available and possible future therapeutic agents. Cutting-edge and wide ranging, Alzheimer's Disease: Methods and Protocols provides ready access to proven, reproducible methods for elucidating the molecular basis of this most common senile dementia. |
| Additional Information |
| BISAC Categories: - Medical | Neurology - Science | Life Sciences - Molecular Biology - Medical | Geriatrics |
| Dewey: 616.831 |
| LCCN: 99017627 |
| Series: Methods in Molecular Medicine |
| Physical Information: 1.23" H x 6.36" W x 9.38" (1.75 lbs) 408 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future. |