Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods Contributor(s): Fuxreiter, Monika (Editor) |
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ISBN: 1138198889 ISBN-13: 9781138198883 Publisher: CRC Press OUR PRICE: $92.14 Product Type: Paperback - Other Formats Published: April 2018 |
Additional Information |
BISAC Categories: - Science | Life Sciences - Biology - Science | Chemistry - Physical & Theoretical - Science | Physics - General |
Dewey: 572.633 |
Series: Series in Computational Biophysics |
Physical Information: 479 pages |
Descriptions, Reviews, Etc. |
Publisher Description: The Latest Developments on the Role of Dynamics in Protein Functions Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles. The book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues:
While dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure-function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins. |