| Inflammation in the Pathogenesis of Chronic Diseases: The Cox-2 Controversy 2007 Edition Contributor(s): Harris, Randall E. (Editor) |
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ISBN: 1402056877 ISBN-13: 9781402056871 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover - Other Formats Published: April 2007 Annotation: In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy," a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer's disease and otherneurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents. |
| Additional Information |
| BISAC Categories: - Medical | Diseases - Medical | Oncology - General - Medical | Immunology |
| Dewey: 616.047 |
| LCCN: 2009277937 |
| Series: Subcellular Biochemistry |
| Physical Information: 0.81" H x 6.14" W x 9.21" (1.44 lbs) 324 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives. |