| Yeast as a Tool in Cancer Research 2007 Edition Contributor(s): Nitiss, John L. (Editor), Heitman, Joseph (Editor) |
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ISBN: 1402059620 ISBN-13: 9781402059629 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover - Other Formats Published: May 2007 Annotation: Yeast is an experimental system that has led to critical discoveries in cell and molecular biology. The wide range of tools available in yeast has also made it an important system in many areas relevant to cancer including anti-cancer drug discovery, mechanisms of cell cycle control, and biological responses to stress. The present volume represents a state-of-the-art description of many areas of cancer research where yeast based systems are proving particularly valuable. This volume is of particular value to cancer researchers who lack extensive experience with yeast, but are interested in current results with this highly relevant experimental system. |
| Additional Information |
| BISAC Categories: - Medical | Oncology - General - Medical | Research - Medical | Pharmacology |
| Dewey: 614.599 |
| Physical Information: 0.9" H x 6.34" W x 9.45" (1.92 lbs) 452 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Leland H. Hartwell Director, Fred Hutchinson Cancer Research Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be the most useful single-celled organism for studying the fundamental aspects of cell biology. Resources are now available for yeast that greatly simplify and empower new investigations, like the presence of strains with each gene deleted, each protein tagged and databases on protein-protein interactions, gene regulation, and subcellular protein location. A powerful combination of genetics, cell biology, and biochemistry employed by thousands of yeast researchers has unraveled the complexities of numerous cellular processes from mitosis to secretion and even uncovered new insights into prion diseases and the role of prions in normal biology. These insights have proven, time and again, to foretell the roles of proteins and pathways in human cells. The collection of articles in this volume explores the use of yeast in pathway analysis and drug discovery. Yeast has, of course, supplied mankind's most ubiquitous drug for thousands of years. In one aspect, the role of yeast in drug discovery is much like the role of yeast in other areas of biology. Yeast offers the power of genetics and a repetoire of resources available in no other organism. Using yeast in the study of drug targets and metabolism can help to make a science of what has been largely an empirical activity. A science of drug discovery would permit rigorous answers to important questions. |