| Atherosclerosis, Hypertension and Diabetes 2003 Edition Contributor(s): Pierce, Grant N. (Editor), Nagano, Makoto (Editor), Zahradka, Peter (Editor) |
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ISBN: 1402073119 ISBN-13: 9781402073113 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: April 2003 Annotation: This volume is devoted to atherosclerosis, hypertension, and diabetes, three of the most important disease conditions in the world today. Nutritional intervention, cholesterol lowering agents, lipids themselves, particularly oxidized LDL, protein modification by ADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are all discussed in the context of atherosclerotic cardiovascular disease. The hypertension section focuses on factors that may be responsible for high blood pressure, such as genetic predisposition, vascular hyperplasia and remodeling, insulin resistance, neurological aspects such as hypothalamic peptides. Also discussed are the possible contributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drug delivery for treatment of hypertension is also a focus. As for diabetes, the risk factors and mechanisms responsible for diabetic vascular and cardiac dysfunction are discussed. Lipid profile changes and fibrinolysis in diabetic patients is detailed, along with adipogenesis, diabetic cardiomyopathy, energy metabolism in the diabetic heart, vanadate as an alternative to insulin, insulin resistance mechanisms, and neurotransmitters as targets for the prevention of cardiovascular disease and diabetes. These manuscripts were invited from scientists who presented state of the art lectures at the XVII World Congress of the International Society for Heart Research held in Winnipeg in July 2001. |
| Additional Information |
| BISAC Categories: - Medical | Cardiology - Medical | Internal Medicine |
| Dewey: 616.12 |
| LCCN: 2002192487 |
| Series: Progress in Experimental Cardiology |
| Physical Information: 1.15" H x 6.54" W x 9.48" (1.86 lbs) 492 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Thistext, as the tide states, is acompilationofpapersdevoted to the studyofath- erosclerosis, hypertensionanddiabetes.Thesethree distinctdisease entities, although not entirely unrelated, are three ofthe most important disease conditions in the world today.As such, this volumeofresearch papers isofobvious medical impor- tance.Thejustificationofthe energy, time and financial resources directed towards the studyofeachofthese three diseases requiressome discussion. The majority of papers amongst the three diseases that are discussed in this volume are dedicated to the studyofatherosclerosis.This is not by accident.Car- diovasculardisease isthenumberonekillertodayintheworld. IntheUnitedStates almost61 millionAmericanshaveoneormoreformsofcardiovasculardisease.These diseases claimed nearly 1million lives in 1998 alone.Although approximately 80% ofthosewho dieofcardiovasculardisease are 65 yearsofageorolder, asignificant numberofpeople are killed by cardiovascular disease below the ageof65.Ather- osclerotic heart disease in the eoronary vaseulature eausedapproximately million deaths in the United States in 1998.At least 12,400,000people are alive todayin the United States with a historyofmyocardial infarctions or ehest pain or both. Clearly, atherosclerotie disease inthe heart isamajormedicalproblem.This disease affeetsbothmenandwomen.Althoughmen are more likelyto experienee aheart attaekand are atgreater risk for eardiovaseular disease, more then ofthe people alive today with a historyofheart attacks or angina are females. As weIl, women whodo havemyoeardialinfarctionsare twice aslikely to diefromtheeventwithin afew weeks.Atheroscleroticvasculardisease isnotlimitedtojustthe heart.Anath- erosclerotic ischemic event is the primary causeofstroke today.Although it isnot weIl appreciated, stroke is the number 3 killer inAmerica today and the leading causeofdebilitatingneurological damage.Atherosclerotic vascular disease therefore, has acostintermsofhuman life, qualityoflifeandfinancialburden today thatno otherdisease canmatch.Theseriousnessofthis medicalproblemdemands research attention. |