| Drug Discovery and Development Softcover Repri Edition Contributor(s): Williams, Michael (Author), Malick, Jeffrey B. (Author) |
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ISBN: 1461291801 ISBN-13: 9781461291800 Publisher: Humana OUR PRICE: $161.49 Product Type: Paperback - Other Formats Published: September 2011 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacy - Medical | Pharmacology |
| Dewey: 615.1 |
| Physical Information: 0.94" H x 6.14" W x 9.21" (1.43 lbs) 448 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar- maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera- peutic entities, as evidenced by Sir James Black's H -receptor an- 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex- pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy- chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de- velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need. |