| Neurochemical Systems Softcover Repri Edition Contributor(s): Lajtha, Abel (Author) |
|
 |
ISBN: 1468470205 ISBN-13: 9781468470208 Publisher: Springer OUR PRICE: $52.24 Product Type: Paperback - Other Formats Published: January 2013 |
| Additional Information |
| BISAC Categories: - Medical | Neuroscience - Science | Life Sciences - Biology |
| Dewey: 612.8 |
| Physical Information: 1.41" H x 7" W x 10" (2.65 lbs) 671 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The content of Volume 8 of the Handbook of Neurochemistry is a perfect example and sample of what occupies neurochemists in the late 1980s. What occupies them are questions, concepts, and technology that either did not start with the nervous system, or rapidly moved out of its exclusivity (see, for in- stance, chapters on neurotensin, beta-lipotropin, behavioral and neurochemical effects of ACTH, cholecystokinin, etc.). Thus, the neurochemist is more and more seen as a biochemist occupied by questions, concepts, and technology that are not unique to the nervous system, even though the ultimate substrate of these questions, as well as the ultimate functions so studied and occasionally explained, are of the nervous system. Look at the case of the hypothalamic hypophysiotropic peptides, also called hypothalamic releasing factors, or hypothalamic releasing hormones. These are all small-to-medium-size polypeptides originally characterized in ex- tracts of the hypothalamus on the basis of bioassays directed at studying their effects on one or another of the secretions of the adenohypophysis. We know now that TRFs (See Chapter 8), the thyrotropin and prolactin releasing factor, somatostatin, the hypothalamic inhibitor of the secretion of growth hormone, as well as LRF, the hypothalamic decapeptide stimulating the secretion of pituitary gonadotropins, are to be found in parts of the brain other than the hypothalamus, where their function is obviously not hypophysiotropic. Such is also the case for CRF-the corticotropin and beta-endorphin releasing factor. |