| The Biology and Pathology of Innate Immunity Mechanisms 2002 Edition Contributor(s): Keisari, Yona (Editor), Ofek, Itzhak (Editor) |
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ISBN: 1475786476 ISBN-13: 9781475786477 Publisher: Springer OUR PRICE: $161.49 Product Type: Paperback - Other Formats Published: March 2013 |
| Additional Information |
| BISAC Categories: - Medical | Immunology - Medical | Infectious Diseases - Medical | Microbiology |
| Dewey: 616.079 |
| Series: Advances in Experimental Medicine and Biology |
| Physical Information: 0.72" H x 6.14" W x 9.21" (1.07 lbs) 330 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors. |