Techniques to Investigate Mitochondrial Function in Neurons 2017 Edition Contributor(s): Strack, Stefan (Editor), Usachev, Yuriy M. (Editor) |
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ISBN: 1493968882 ISBN-13: 9781493968886 Publisher: Humana OUR PRICE: $161.49 Product Type: Hardcover Published: March 2017 |
Additional Information |
BISAC Categories: - Medical | Neuroscience - Science | Life Sciences - Neuroscience |
Dewey: 612.8 |
LCCN: 2017934469 |
Series: Neuromethods |
Physical Information: 0.81" H x 7" W x 10" (1.86 lbs) 344 pages |
Descriptions, Reviews, Etc. |
Publisher Description: This volume describes a broad spectrum of experimental approaches for investigating structure, function, and transport of neuronal mitochondria in health and disease. Most of these approaches were only recently developed and range from electron tomography-based 3D reconstruction of mitochondrial cristae to patch clamp recording from mitochondria in intact neurons. The chapters in this book cover topics such as mitochondrial proteomics, fluorescence lifetime imaging, respirometry and mitophagy, as well as optical approaches based on the use of genetically engineered fluorescent sensors for monitoring synaptic ATP and axonal ROS generation, mitochondrial Ca2+ cycling and pH changes, and mitochondrial dynamics and axonal trafficking in live neurons. Each chapter also discusses difficulties, tips, tricks, and precautions to take. Neuromethods series style chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
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