| Oxidative Neural Injury 2009 Edition Contributor(s): Veasey, Sigrid C. (Editor) |
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ISBN: 1603273417 ISBN-13: 9781603273411 Publisher: Humana OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: June 2009 Annotation: This book examines the current evidence and research supporting the importance of oxidative injury in selected animal models of both neurodegenerative diseases and neural injury. Each chapter discusses oxidative injury in a selected model, analyzing the major cellular mechanisms that underpin the progression of neural injury. In addition to the analysis of these models, each chaptera (TM)s purpose is to not only relate, but to also contrast the specific injury across models as a way of identifying the common and unique pathways of oxidative neural injury. Through this, each author presents possible fertile future directions for translational research for the identification of possible therapeutics. |
| Additional Information |
| BISAC Categories: - Medical | Neuroscience - Medical | Neurology - Science | Life Sciences - Biochemistry |
| Dewey: 616.804 |
| LCCN: 2009921900 |
| Series: Contemporary Clinical Neuroscience |
| Physical Information: 0.56" H x 6.14" W x 9.21" (1.11 lbs) 218 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation 1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes 2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer's disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan 4-6]. Today, his research and mentorship have positively influenced the work of hundreds of scientists in this field. We dedicate this book to Dr. Earl R. Stadtman (1912-2008), in celebration of his passion for science and his superior collaborative and mentorship skills. This book is comprised of three sections. The first describes the valuable roles reactive oxygen species (ROS) and reactive nitrogen species (RNS) play in cellular biology. The second section provides an overview of redox imbalance injury with effects on mitochondria, signaling, endoplasmic reticular function, and on aging in general. The third section takes these mechanisms to neurodegenerative disorders and provides a state-of-the-art look at the roles redox imbalances play in age-related susceptibility to disease and in the disease processes. In the first section we attempt to answer a question posed by Dr. Stadtman, ''Why have cells selected reactive oxygen species to regulate cell signaling events'' 7]. |