| Reducing, Refining and Replacing the Use of Animals in Toxicity Testing Contributor(s): Allen, Dave (Editor), Waters, Mike D. (Editor) |
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ISBN: 1849736529 ISBN-13: 9781849736527 Publisher: Royal Society of Chemistry OUR PRICE: $212.80 Product Type: Hardcover - Other Formats Published: October 2013 |
| Additional Information |
| BISAC Categories: - Medical | Toxicology - Non-classifiable - Science | Life Sciences - Biochemistry |
| Dewey: 615.907 |
| Series: Issues in Toxicology |
| Physical Information: 1.14" H x 6.45" W x 9.38" (1.58 lbs) 362 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. Many methods currently involve laboratory animals. Alternative procedures are now being developed which reduce, refine, or replace animal usage. Aimed at postgraduates, academics and industrialists, this book describes the ever-expanding "toolbox" of methods now available. These often result from our growing understanding of the biochemical pathways that mediate toxicity. By combining various techniques to build a "weight of evidence", toxicologists are developing mechanistically based alternatives to experimentation on live animals. This text also emphasizes the importance of adequate test validation, reliability and relevance. |
Contributor Bio(s): Waters, Mike D.: - Michael D. Waters, holds a Ph.D. in Biochemistry from the University of North Carolina School of Medicine at Chapel Hill and a B.S. in Pre-medicine (Chemistry and Biology) from Davidson College. He is a former government scientist with more than 35 years of experience in research and research management positions at EPA and NIH/NIEHS and six years of private sector experience as Chief Scientific Officer at Integrated Laboratory Systems, Inc. His research interests have centered on the evaluation of chemically-induced mutations and altered molecular expression in the etiology of genetic disease. He is a widely-published scientist having published well over 100 peer-reviewed in authoritative international scientific journals. He has edited Mutation Research-Reviews for nearly 20 years and has held adjunct professorships at both the University of North Carolina and at Duke University for many years. He served as President of both the Environmental Mutagen Society and the International Association of Environmental Mutagen Societies (now the Environmental Mutagenesis and Genomics Society and the International Association of Environmental Mutagenesis and Genomics Societies, with more than seven thousand members worldwide). The databases he has developed and a number of his publications are recognized as important advances that have significantly impacted the fields of genetic toxicology, carcinogenesis, toxicogenomics, and risk assessment. |