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A neuroscientist walks out of her life and isolates herself in the woods, intending to blow the whistle on a pharmaceutical company and its creativity drug gone wrong. A recently orphaned graduate school dropout is hired as a "literary detective" to decode the work of a mysterious Internet poet who writes about disappearances and murders with an inexplicably precise knowledge of private details. And a virologist discovers her identity has been stolen by a conceptual artist in whose stories someone always goes missing. Ali, James, and Celia exist in worlds where implausibilities that once belonged to science fiction, ancient superstition, or dystopian visions are real or impending.

Set in great cities, remote regions, and deadly borderlands, Michael Helm's groundbreaking novel, After James, is told in three parts, each gesturing toward a type of genre fiction: the gothic horror, the detective novel, and the apocalyptic. Science and art become characters, and secrets form, hidden in the codes of genetic sequences, poems, and the patterns of political violence. Part to part, elements repeat--otherworldly weather, disturbing artwork, buried corpses--and amid these echoes, a larger mystery arises, one that joins artifice to nature, and fiction to reality, delivering us into the troubling wonder of the present world.