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Sixteen-year-old Silver Melody lives in a world where 80% of the population has modified their DNA. Known as the altereds, those people now possess enhancements like wings, tails, and increased strength or intelligence. Although Silver's parents created the nanite pill used to deliver these genetic modifications, Silver is proud of her unadjusted state.

However, when the president declares all unadjusteds must take a nanite, Silver has no choice but to flee the city with her father and some friends to prevent the extinction of the unadjusteds.

With Silver's mother in prison for treason, Silver's father is the unadjusteds' only hope at finding a cure. But time is running out as Silver's father is captured by the president's almost immortal army. Vicious hellhounds are on Silver's trail, and her only chance to recover her father involves teaming up with a new group of unlikely friends before all humanity is lost.