Cancer Stem Cell Resistance to Targeted Therapy 2019 Edition Contributor(s): Maccalli, Cristina (Editor), Todaro, Matilde (Editor), Ferrone, Soldano (Editor) |
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ISBN: 3030166260 ISBN-13: 9783030166267 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: August 2020 |
Additional Information |
BISAC Categories: - Medical | Oncology - General - Medical | Immunology - Science | Life Sciences - Molecular Biology |
Dewey: 611.018 |
Physical Information: 0.58" H x 6.14" W x 9.21" (0.87 lbs) 256 pages |
Descriptions, Reviews, Etc. |
Publisher Description: This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients. |