| Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R 2019 Edition Contributor(s): Schiesser, William E. (Author) |
|
 |
ISBN: 3030176355 ISBN-13: 9783030176358 Publisher: Springer OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: June 2019 |
| Additional Information |
| BISAC Categories: - Medical | Allied Health Services - Medical Technology - Mathematics | Applied - Medical | Oncology - General |
| Dewey: 003.3 |
| Physical Information: 0.31" H x 6.14" W x 9.21" (0.78 lbs) 112 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The focus of this book is a detailed discussion of a dual cancer vaccine (CV)-immune checkpoint inhibitor (ICI) mathematical model formulated as a system of partial differential equations (PDEs) defining the spatiotemporal distribution of cells and biochemicals during tumor growth. A computer implementation of the model is discussed in detail for the quantitative evaluation of CV-ICI therapy. The coding (programming) consists of a series of routines in R, a quality, open-source scientific computing system that is readily available from the internet. The routines are based on the method of lines (MOL), a general PDE algorithm that can be executed on modest computers within the basic R system. The reader can download and use the routines to confirm the model solutions reported in the book, then experiment with the model by varying the parameters and modifying/extending the equations, and even studying alternative models with the PDE methodology demonstrated by the CV-ICI model. Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R facilitates the use of the model, and more generally, computer- based analysis of cancer immunotherapy mathematical models, as a step toward the development and quantitative evaluation of the immunotherapy approach to the treatment of cancer. To download the R routines, please visit: http: //www.lehigh.edu/ wes1/ci_download |