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Protein Instability at Interfaces During Drug Product Development: Fundamental Understanding, Evaluation, and Mitigation 2021 Edition
Contributor(s): Li, Jinjiang (Editor), Krause, Mary E. (Editor), Tu, Raymond (Editor)
ISBN: 3030571769     ISBN-13: 9783030571764
Publisher: Springer
OUR PRICE:   $151.99  
Product Type: Hardcover
Published: February 2021
Qty:
Additional Information
BISAC Categories:
- Medical | Pharmacy
- Medical | Pharmacology
- Science | Chemistry - Physical & Theoretical
Physical Information: 0.81" H x 6.14" W x 9.21" (1.46 lbs) 338 pages
 
Descriptions, Reviews, Etc.
Publisher Description:

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.