Progress in the Chemistry of Organic Natural Products 102 2016 Edition Contributor(s): Kinghorn, A. Douglas (Editor), Falk, Heinz (Editor), Gibbons, Simon (Editor) |
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ISBN: 3319331701 ISBN-13: 9783319331706 Publisher: Springer OUR PRICE: $161.49 Product Type: Hardcover - Other Formats Published: July 2016 |
Additional Information |
BISAC Categories: - Science | Chemistry - Organic - Medical | Biochemistry - Medical | Pharmacy |
Dewey: 547 |
Series: Progress in the Chemistry of Organic Natural Products |
Physical Information: 252 pages |
Descriptions, Reviews, Etc. |
Publisher Description: The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its "reverse-pharmacology" focus. |