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Progress in the Chemistry of Organic Natural Products 102 2016 Edition
Contributor(s): Kinghorn, A. Douglas (Editor), Falk, Heinz (Editor), Gibbons, Simon (Editor)
ISBN: 3319331701     ISBN-13: 9783319331706
Publisher: Springer
OUR PRICE:   $161.49  
Product Type: Hardcover - Other Formats
Published: July 2016
Qty:
Temporarily out of stock - Will ship within 2 to 5 weeks
Additional Information
BISAC Categories:
- Science | Chemistry - Organic
- Medical | Biochemistry
- Medical | Pharmacy
Dewey: 547
Series: Progress in the Chemistry of Organic Natural Products
Physical Information: 252 pages
 
Descriptions, Reviews, Etc.
Publisher Description:

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its "reverse-pharmacology" focus.
The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.