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This book presents and develops several important concepts of speech enhancement in a simple but rigorous way. Many of the ideas are new; not only do they shed light on this old problem but they also offer valuable tips on how to improve on some well-known conventional approaches. The book unifies all aspects of speech enhancement, from single channel, multichannel, beamforming, time domain, frequency domain and time-frequency domain, to binaural in a clear and flexible framework. It starts with an exhaustive discussion on the fundamental best (linear and nonlinear) estimators, showing how they are connected to various important measures such as the coefficient of determination, the correlation coefficient, the conditional correlation coefficient, and the signal-to-noise ratio (SNR). It then goes on to show how to exploit these measures in order to derive all kinds of noise reduction algorithms that can offer an accurate and versatile compromise between noise reduction and speech distortion.